Energy & Endurance
Mitochondria, stamina and fatigue.
8 peptides · 31 linked sources
Energy & Endurance: 8 peptides and related compounds in this index have at least one researched benefit that sources link to energy & endurance. Those with approved or trial-backed evidence: SS-31, Vitamin B12, L-carnitine.
| Peptide | Evidence label | What sources discuss for this goal |
|---|---|---|
| SS-31 | Approved (specific use) | Mitochondrial function, animal; Exercise tolerance, animal and anecdotal |
| Vitamin B12 | Approved (specific use) | Treats B12 deficiency; Clearer thinking when deficient |
| FOXO4-DRI | Preclinical | Clears senescent cells, mice |
| MOTS-c | Preclinical | Insulin sensitivity, animal; Exercise capacity, animal; Endurance, anecdotal |
| L-carnitine | Approved (specific use) | Exercise recovery; Treats carnitine deficiency |
| NAD+ | Early human | Mitochondria and sirtuins, lab data; Energy and focus, anecdotal |
| Selank | Early human | Less fatigue, small studies |
| Lipo-C | Unstudied | Energy from B12, unproven |
Listed when one of a peptide's three researched benefits relates to energy & endurance. Strongest evidence first. Inclusion is not a recommendation, and some listed effects are unproven or failed in trials.
Approved (specific use)
Approved by the FDA (or a major regulator) for at least one specific use. Approval covers that use only, not the other benefits listed.
- SS-31
Mitochondrial function, animal, Muscle strength in Barth syndrome, Exercise tolerance, animal and anecdotal
01 Mitochondrial function, animal
Side effects, quotes and full profile03 Exercise tolerance, animal and anecdotal
- Vitamin B12
Treats B12 deficiency, Protects nerves in deficiency, Clearer thinking when deficient
- L-carnitine
Modest weight loss, Exercise recovery, Treats carnitine deficiency
Early human
Small, short, old, unblinded or single-group human studies.
- NAD+
Raises NAD+ levels, Mitochondria and sirtuins, lab data, Energy and focus, anecdotal
02 Mitochondria and sirtuins, lab data
Side effects, quotes and full profile03 Energy and focus, anecdotal
- Selank
Less anxiety, small open studies, Less fatigue, small studies, Immune modulation, small study
Side effects, quotes and full profile02 Less fatigue, small studies
Preclinical
Mostly cell and animal studies. Human effects unknown.
- FOXO4-DRI
Clears senescent cells, mice, Chemo toxicity protection, mice, Kidney function, mice
Side effects, quotes and full profile01 Clears senescent cells, mice
- MOTS-c
Insulin sensitivity, animal, Exercise capacity, animal, Endurance, anecdotal
01 Insulin sensitivity, animal
02 Exercise capacity, animal
Side effects, quotes and full profile03 Endurance, anecdotal
Unstudied
No direct studies of this product or blend. Anecdote and component data only.
- Lipo-C
Fat burning, unproven, Liver fat handling, nutrient data only, Energy from B12, unproven
Side effects, quotes and full profile03 Energy from B12, unproven
- Energy (B12 component): B12 corrects fatigue/anemia only in documented deficiency; little evidence of energy boost in non-deficient peoplemeta-analysis cited in pharmacy review31
Questions about energy & endurance
Which peptides are discussed for energy & endurance?
SS-31, Vitamin B12, FOXO4-DRI, MOTS-c, L-carnitine, NAD+, Selank, Lipo-C.
Which have the strongest evidence for energy & endurance?
Labelled approved or trial-backed: SS-31, Vitamin B12, L-carnitine. Approval covers specific uses only.
Is any of this a recommendation?
No. humanpeptides.fyi makes no claims of its own. Each entry reports what cited sources say, with links. Talk to a licensed clinician.