Immunity

T-cells, vaccine response and inflammation.

4 peptides · 18 linked sources

Immunity: 4 peptides and related compounds in this index have at least one researched benefit that sources link to immunity. Those with approved or trial-backed evidence: Thymosin Alpha-1.

Peptides discussed for immunity, at a glance
PeptideEvidence labelWhat sources discuss for this goal
Thymosin Alpha-1Trial-backedChronic hepatitis B; Stronger vaccine response; Sepsis, mixed results
VIPEarly humanImmune balance, small studies; Mold-related illness, small studies
ThymalinEarly humanImmune restoration, small trial; Stem cell activation, lab
SelankEarly humanImmune modulation, small study

Listed when one of a peptide's three researched benefits relates to immunity. Strongest evidence first. Inclusion is not a recommendation, and some listed effects are unproven or failed in trials.

Trial-backed

Larger randomized human trials exist, positive or negative, but no US approval for the uses discussed.

  1. Thymosin Alpha-1

    Chronic hepatitis B, Stronger vaccine response, Sepsis, mixed results

    01 Chronic hepatitis B

    • Chronic hepatitis B: RCTs reported HBV DNA/HBeAg clearance and ALT normalization with mild side effects, though results mixedhuman RCTs12

    02 Stronger vaccine response

    • Vaccine response in older adults: double-blind RCT found improved influenza antibody responses in elderly men; higher natural Ta1 levels linked to less waning after COVID vaccinationhuman RCT + cohort345

    03 Sepsis, mixed results

    • Sepsis: phase 3 TESTS RCT (n=1,089) found no mortality benefit (23.4% vs 24.1%), possible subgroup benefit in age 60+/diabeteshuman RCT, negative
    • Cancer immunotherapy adjunct: preliminaryreview + small phase 2

    Sources for this benefit 678

    Side effects, quotes and full profile

Early human

Small, short, old, unblinded or single-group human studies.

  1. VIP

    Immune balance, small studies, Erectile function, approved abroad, Mold-related illness, small studies

    01 Immune balance, small studies

    • Anti-inflammatory/immune modulation: VIP suppresses pro-inflammatory pathways, favoring Th2/Treg responses; inhaled VIP in 20 sarcoidosis patients reduced lung TNF-alpha and increased regulatory T cellsreview + small open human phase 2910

    03 Mold-related illness, small studies

    • Mold-related illness (CIRS): open-label study of 20 refractory patients on intranasal VIP reported symptom and inflammatory-marker improvement (uncontrolled, single practitioner group)
    • COVID respiratory failure: IV aviptadil failed primary endpoints; phase 3 TESICO stopped for futilityhuman RCTs, negative

    Sources for this benefit 111213

    Side effects, quotes and full profile
  2. Thymalin

    Immune restoration, small trial, Longevity claim, Stem cell activation, lab

    01 Immune restoration, small trial

    • Restores immune function (T-cell/lymphocyte counts): in severe older COVID-19 patients, thymalin increased lymphocyte recovery and was associated with lower hospital mortality (19.4% vs 40.9%)small single-center single-blind RCT1415

    03 Stem cell activation, lab

    • Activates differentiation of human hematopoietic stem cellsin vitro16
    Side effects, quotes and full profile
  3. Selank

    Less anxiety, small open studies, Less fatigue, small studies, Immune modulation, small study

    03 Immune modulation, small study

    • Immunomodulation: altered Th1/Th2 cytokine balance and IL-6 gene expression in patients with anxiety-asthenic disorderssmall human study1718
    Side effects, quotes and full profile

Questions about immunity

Which peptides are discussed for immunity?

Thymosin Alpha-1, VIP, Thymalin, Selank.

Which have the strongest evidence for immunity?

Labelled approved or trial-backed: Thymosin Alpha-1. Approval covers specific uses only.

Is any of this a recommendation?

No. humanpeptides.fyi makes no claims of its own. Each entry reports what cited sources say, with links. Talk to a licensed clinician.

Before you go in

humanpeptides.fyi is an educational index for adults. It summarizes and links to what others have published and reported about peptides and related compounds studied or used in humans. It is not medical advice and gives no dosing guidance. Many listed compounds are not approved for human use, and listing one is not a recommendation. Anecdotes are unverified. Images are AI-generated. By continuing, you agree to the Disclaimer and Terms of Use and the Privacy Notice.

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