Hormones & Fertility

Growth hormone, testosterone and fertility signalling.

10 peptides · 30 linked sources

Hormones & Fertility: 10 peptides and related compounds in this index have at least one researched benefit that sources link to hormones & fertility. Those with approved or trial-backed evidence: HCG, HGH (Somatropin).

Peptides discussed for hormones & fertility, at a glance
PeptideEvidence labelWhat sources discuss for this goal
HCGApproved (specific use)Keeps testicular function on TRT; Treats male hypogonadism; Size, libido and mood, anecdotal
CJC-1295 with DACEarly humanDays-long GH and IGF-1 rise
SermorelinEarly humanNatural-rhythm GH and IGF-1
KisspeptinEarly humanLH and testosterone rise; Safer IVF trigger
CJC-1295 without DACPreclinicalNatural-pattern GH pulses, theoretical
IpamorelinPreclinicalSelective GH release, animal
CJC-1295 + IpamorelinUnstudiedAmplified GH pulses, theoretical
Tesamorelin + IpamorelinUnstudiedSynergistic GH release, theoretical
HGH (Somatropin)Approved (specific use)Treats growth failure in children
IGF-1 LR3PreclinicalNative IGF-1 is an approved drug

Listed when one of a peptide's three researched benefits relates to hormones & fertility. Strongest evidence first. Inclusion is not a recommendation, and some listed effects are unproven or failed in trials.

Approved (specific use)

Approved by the FDA (or a major regulator) for at least one specific use. Approval covers that use only, not the other benefits listed.

  1. HCG

    Keeps testicular function on TRT, Treats male hypogonadism, Size, libido and mood, anecdotal

    01 Keeps testicular function on TRT

    • Maintains intratesticular testosterone and spermatogenesis in men on testosterone therapylow-dose 250-500 IU every other day; human randomized study + retrospective cohort123

    02 Treats male hypogonadism

    • Treats male hypogonadotropic hypogonadism (raises endogenous testosterone) and induces ovulation in infertile womenFDA label456

    03 Size, libido and mood, anecdotal

    • TRT users report restored testicular size, better libido, sensitivity and semen volumeanecdotal/Reddit789
    Side effects, quotes and full profile
  2. HGH (Somatropin)

    Leaner body composition, Treats growth failure in children, Less visceral fat, better lipids

    02 Treats growth failure in children

    • Treats growth failure in children (GHD, Turner, Prader-Willi, SGA, idiopathic short stature) and adult GH deficiencyFDA label2829
    Side effects, quotes and full profile

Early human

Small, short, old, unblinded or single-group human studies.

  1. CJC-1295 with DAC

    Days-long GH and IGF-1 rise, Visceral fat, trial halted, Sleep, muscle and fat, unproven claims

    01 Days-long GH and IGF-1 rise

    • Raises GH 2-10 fold for >6 days and IGF-1 1.5-3 fold for 9-11 days after a single dose; weekly/biweekly dosing kept IGF-1 elevated up to 28 dayshuman RCT, healthy adults1011
    Side effects, quotes and full profile
  2. Sermorelin

    Natural-rhythm GH and IGF-1, Lean mass gain, small study, Deeper sleep, anecdotal

    01 Natural-rhythm GH and IGF-1

    • Raises endogenous GH and IGF-1 while preserving physiological pulsatilityhuman studies1213
    Side effects, quotes and full profile
  3. Kisspeptin

    LH and testosterone rise, Desire and arousal, Safer IVF trigger

    01 LH and testosterone rise

    • Potently stimulates LH and raises testosterone in men: continuous kisspeptin-10 infusion increased LH pulse frequency and testosterone from 16.6 to 24.0 nmol/Lhuman study1415

    03 Safer IVF trigger

    • Safer IVF trigger: kisspeptin-54 triggered oocyte maturation in women at high OHSS risk with no moderate/severe OHSSphase 2 human RCTs161718
    Side effects, quotes and full profile

Preclinical

Mostly cell and animal studies. Human effects unknown.

  1. CJC-1295 without DAC

    Natural-pattern GH pulses, theoretical, Deeper sleep, anecdotal, Body composition, anecdotal

    01 Natural-pattern GH pulses, theoretical

    • Short pulsatile GH release mimicking natural GHRH; used for GH/IGF-1 supportmechanistic; no dedicated human trial of the no-DAC form found - published human CJC data are for the DAC version192021
    Side effects, quotes and full profile
  2. Ipamorelin

    Selective GH release, animal, Gut motility, negative trial, Sleep and body composition, anecdotal

    01 Selective GH release, animal

    • Selective GH release: in rat pituitary cells, rats and swine, ipamorelin released GH without ACTH/cortisol rise even at >200x the GH ED50animal2223
    Side effects, quotes and full profile
  3. IGF-1 LR3

    Muscle growth, no human data, Growth in catabolic rats, Native IGF-1 is an approved drug

    03 Native IGF-1 is an approved drug

    • Native IGF-1 (mecasermin) is FDA-approved for severe primary IGF-1 deficiency in children - shows IGF-1's growth-promoting effects but does not validate LR3FDA label30
    Side effects, quotes and full profile

Unstudied

No direct studies of this product or blend. Anecdote and component data only.

  1. CJC-1295 + Ipamorelin

    Amplified GH pulses, theoretical, Better sleep, anecdotal, Body recomposition, anecdotal

    01 Amplified GH pulses, theoretical

    • Amplified, pulsatile GH release via synergistic GHRH + ghrelin-receptor stimulationmechanistic; no blend trial242519
    Side effects, quotes and full profile
  2. Tesamorelin + Ipamorelin

    Synergistic GH release, theoretical, Belly fat, via tesamorelin, Deeper sleep, anecdotal

    01 Synergistic GH release, theoretical

    • Synergistic GH release: GHRH plus a GHRP produced more GH than the sum of either alone in healthy menhuman study with GHRP, not ipamorelin/tesamorelin specifically2627
    Side effects, quotes and full profile

Questions about hormones & fertility

Which peptides are discussed for hormones & fertility?

HCG, CJC-1295 with DAC, Sermorelin, Kisspeptin, CJC-1295 without DAC, Ipamorelin, CJC-1295 + Ipamorelin, Tesamorelin + Ipamorelin, HGH (Somatropin), IGF-1 LR3.

Which have the strongest evidence for hormones & fertility?

Labelled approved or trial-backed: HCG, HGH (Somatropin). Approval covers specific uses only.

Is any of this a recommendation?

No. humanpeptides.fyi makes no claims of its own. Each entry reports what cited sources say, with links. Talk to a licensed clinician.

Before you go in

humanpeptides.fyi is an educational index for adults. It summarizes and links to what others have published and reported about peptides and related compounds studied or used in humans. It is not medical advice and gives no dosing guidance. Many listed compounds are not approved for human use, and listing one is not a recommendation. Anecdotes are unverified. Images are AI-generated. By continuing, you agree to the Disclaimer and Terms of Use and the Privacy Notice.

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