CJC-1295 without DAC
CJC-1295 without DAC (Modified GRF 1-29)
What is CJC-1295 without DAC?
CJC-1295 without DAC: Modified GRF(1-29), a tetra-substituted GHRH analogue (D-Ala2, Gln8, Ala15, Leu27) with ~30 min half-life that produces short GH pulses rather than the multi-day elevation of the DAC version. The sources cited here most often discuss it for: Natural-pattern GH pulses, theoretical; Deeper sleep, anecdotal; Body composition, anecdotal. Evidence label: Preclinical.
- Type
- Peptide
- Family
- Growth Hormone Axis
- Evidence label
- Preclinical (2 of 5)
- Regulatory status
- FDA's compounding safety listing for CJC-1295 (form not specified) cited serious adverse events including increased heart rate and a systemic vasodilatory reaction, and the nomination was later withdrawn.
- Goals discussed
- Hormones & Fertility, Sleep, Muscle & Tone, Fat Loss & Metabolism, Healing & Recovery
- Also called
- Modified GRF (1-29), tetrasubstituted GRF (1-29), Mod GRF 1-29, CJC-1295 no DAC
- Last reviewed
- 2026-10-11
- Modified GRF(1-29), a tetra-substituted GHRH analogue (D-Ala2, Gln8, Ala15, Leu27) with ~30 min half-life that produces short GH pulses rather than the multi-day elevation of the DAC version; not FDA-approved, WADA S2 prohibited.12
Often sold simply as CJC-1295; the published CJC-1295 human trials used the DAC version, so their results do not carry over to Mod GRF 1-29.
Regulatory status FDA's compounding safety listing for CJC-1295 (form not specified) cited serious adverse events including increased heart rate and a systemic vasodilatory reaction, and the nomination was later withdrawn. 3
Names as used in gyms, forums and gray-market listings. Reported, not endorsed; stacks have not been studied as combinations.
FDA has identified serious adverse events associated with CJC-1295 including increased heart rate and systemic vasodilatory reaction.
FDA's safety assessment of CJC-1295 as a nominated compounding substance; the entry does not say which form.
What is CJC-1295 without DAC researched for?
The three outcomes most discussed for CJC-1295 without DAC in the sources below, as those sources report them. humanpeptides.fyi makes no claims of its own: a listed benefit can be unproven or can have failed in trials, and the label on each line says which.
Body composition, anecdotal
- Body composition/recovery changes reported by users after ~8-12 weeks, usually stacked with ipamorelinanecdotal/Reddit6
What do researchers and users say about CJC-1295 without DAC?
The days I don’t take it, I can’t sleep, days I do, I sleep like a rock.
User taking CJC-1295 without DAC combined with ipamorelin, describing sleep on and off days.
I find it damages my sleep. It pushes me too far into deep sleep, and the lack of REM means I wake up groggy and sluggish.
Reply in the same thread from a user with the opposite sleep experience on the CJC-1295 (no DAC) and ipamorelin combination.
What side effects of CJC-1295 without DAC are reported?
- Flushing, injection-site reactions, headache, water retention reported for CJC-1295 generally1
- Long-term safety of chronic GH elevation unknown; research-grade purity concerns1
- Higher overnight heart rate, lower heart-rate variability and worse sleep, reported by one user taking it with ipamorelinanecdotal5
- Waking wide awake in the night, or groggy REM-poor sleep, reported by some users who took it at nightanecdotal5
- A forearm compression sensation late in a cycle, reported by one long-term useranecdotal5
- Serious adverse events including increased heart rate and a systemic vasodilatory reaction cited for CJC-1295, form not specifiedFDA assessment3
What do peptide guides say about CJC-1295 without DAC?
- Dr. Axe Dr. Axe's guide lists the CJC-1295 and ipamorelin pairing as research-only with insufficient evidence, noting the cited human study evaluated CJC-1295 alone, and says WADA bans it. 7
- PepEdHub PepEdHub notes the no-DAC form, Mod GRF 1-29, lasts about 30 minutes in the body and produces short GH pulses, versus 6 to 8 days for the DAC version. 8
- Seek Peptides Seek Peptides lists Mod GRF 1-29 as a short-acting GH releaser that creates pulses, usually paired with GHRP-type peptides for muscle building and recovery. 9
What does the research say, system by system?
Hormones & physiology1
- Acts on pituitary GHRH receptor to release GH (and downstream IGF-1) in brief pulses; 2005 rat study showed acute GH secretion from GRF(1-29) analoguesanimal1
Brain, mood & sleep1
- Anecdotal deeper sleep; some users report disrupted sleep or a raised heart rate10
Weight & metabolism1
- No controlled data; anecdotal fat loss reports5
Muscle1
- No controlled data; theorized via GH/IGF-11
Also notable1
- Requires multiple daily injections (often 2-3x/day or nightly) due to short half-life (community reports)11
How strong is the evidence for CJC-1295 without DAC?
Mechanistic/animal + anecdotal; no human trials of the no-DAC form
Mostly cell and animal studies. Human effects unknown. How tiers work
Questions about CJC-1295 without DAC
What is CJC-1295 without DAC?
Modified GRF(1-29), a tetra-substituted GHRH analogue (D-Ala2, Gln8, Ala15, Leu27) with ~30 min half-life that produces short GH pulses rather than the multi-day elevation of the DAC version. Often sold simply as CJC-1295; the published CJC-1295 human trials used the DAC version, so their results do not carry over to Mod GRF 1-29.
Is CJC-1295 without DAC FDA-approved?
FDA's compounding safety listing for CJC-1295 (form not specified) cited serious adverse events including increased heart rate and a systemic vasodilatory reaction, and the nomination was later withdrawn.
What is CJC-1295 without DAC researched for?
The sources cited on this page most often discuss three outcomes: Natural-pattern GH pulses, theoretical; Deeper sleep, anecdotal; Body composition, anecdotal. Each line above shows what the source reports and how strong that evidence is.
What side effects of CJC-1295 without DAC are reported?
Reported in the cited sources: Flushing, injection-site reactions, headache, water retention reported for CJC-1295 generally; Long-term safety of chronic GH elevation unknown; research-grade purity concerns; Higher overnight heart rate, lower heart-rate variability and worse sleep, reported by one user taking it with ipamorelin. The list is not complete, and few listed risks does not mean a compound is safe.
How strong is the evidence for CJC-1295 without DAC?
Evidence label: Preclinical. Mechanistic/animal + anecdotal; no human trials of the no-DAC form.
What else is CJC-1295 without DAC called?
Names used for it include Modified GRF (1-29), tetrasubstituted GRF (1-29), Mod GRF 1-29, CJC-1295 no DAC.
Does humanpeptides.fyi recommend CJC-1295 without DAC?
No. humanpeptides.fyi makes no claims and no recommendations of its own. It summarizes and links to what others have published and posted. Nothing here is medical advice; talk to a licensed clinician.