Sleep

Falling asleep, staying asleep, deep sleep.

9 peptides · 18 linked sources

Sleep: 9 peptides and related compounds in this index have at least one researched benefit that sources link to sleep. Those with approved or trial-backed evidence: Tirzepatide.

Peptides discussed for sleep, at a glance
PeptideEvidence labelWhat sources discuss for this goal
DSIPEarly humanSleep, small mixed trials
CJC-1295 without DACPreclinicalDeeper sleep, anecdotal
CJC-1295 + IpamorelinUnstudiedBetter sleep, anecdotal
TirzepatideApproved (specific use)Less sleep apnea
CJC-1295 with DACEarly humanSleep, muscle and fat, unproven claims
EpithalonEarly humanMelatonin rhythm, extract data
SermorelinEarly humanDeeper sleep, anecdotal
IpamorelinPreclinicalSleep and body composition, anecdotal
Tesamorelin + IpamorelinUnstudiedDeeper sleep, anecdotal

Listed when one of a peptide's three researched benefits relates to sleep. Strongest evidence first. Inclusion is not a recommendation, and some listed effects are unproven or failed in trials.

Approved (specific use)

Approved by the FDA (or a major regulator) for at least one specific use. Approval covers that use only, not the other benefits listed.

  1. Tirzepatide

    Major weight loss, Blood sugar and heart risk, Less sleep apnea

    03 Less sleep apnea

    • Reduces obstructive sleep apnea severityAHI -25 to -29 events/h vs ~-5 placebo, SURMOUNT-OSA RCT
    • MASH resolution in 44-62% vs 10% placeboSYNERGY-NASH phase 2 RCT

    Sources for this benefit 678

    Side effects, quotes and full profile

Early human

Small, short, old, unblinded or single-group human studies.

  1. DSIP

    Sleep, small mixed trials, Withdrawal relief, old uncontrolled study, Stress-axis calming, early data

    01 Sleep, small mixed trials

    • Sleep: small double-blind insomnia studies were inconsistent - one 1987 study of 14 severe insomniacs reported improved sleep and daytime performance; another 1987 study found no significant effect vs placebo; a 1992 study found only weak, clinically insignificant changessmall human RCTs, mixed123
    Side effects, quotes and full profile
  2. CJC-1295 with DAC

    Days-long GH and IGF-1 rise, Visceral fat, trial halted, Sleep, muscle and fat, unproven claims

    03 Sleep, muscle and fat, unproven claims

    • Claimed sleep, muscle and abdominal fat-loss benefits are extrapolated from GH/IGF-1 elevation and GHRH research; no dedicated CJC-1295 outcome studiespractitioner/vendor review5
    Side effects, quotes and full profile
  3. Epithalon

    Telomere lengthening, lab, Lower mortality, small Russian trials, Melatonin rhythm, extract data

    03 Melatonin rhythm, extract data

    • Melatonin/circadian: epithalamin increased melatonin in elderly with pineal dysfunction; synthetic epitalon data conflicting (failed in rats, reported in primates)human extract + animal9
    • Users report better deep sleep for some, none for othersanecdotal1011
    Side effects, quotes and full profile
  4. Sermorelin

    Natural-rhythm GH and IGF-1, Lean mass gain, small study, Deeper sleep, anecdotal

    03 Deeper sleep, anecdotal

    • Improved/deeper sleep: GHRH pulses increased slow-wave sleep in healthy men (human studies); widely marketed and reported for sleepmedia/anecdotal121314
    Side effects, quotes and full profile

Preclinical

Mostly cell and animal studies. Human effects unknown.

  1. CJC-1295 without DAC

    Natural-pattern GH pulses, theoretical, Deeper sleep, anecdotal, Body composition, anecdotal

    02 Deeper sleep, anecdotal

    • Sleep: users commonly report deeper sleep (anecdotal); parent hormone GHRH increased slow-wave sleep in a 1999 human study (indirect)45
    Side effects, quotes and full profile
  2. Ipamorelin

    Selective GH release, animal, Gut motility, negative trial, Sleep and body composition, anecdotal

    03 Sleep and body composition, anecdotal

    • Sleep quality and body composition: users frequently report deeper sleep and, after 8-12 weeks, recompositionanecdotal/Reddit415
    Side effects, quotes and full profile

Unstudied

No direct studies of this product or blend. Anecdote and component data only.

  1. CJC-1295 + Ipamorelin

    Amplified GH pulses, theoretical, Better sleep, anecdotal, Body recomposition, anecdotal

    02 Better sleep, anecdotal

    • Improved sleep, including one user's 3-month log reporting fixed chronic insomniaanecdotal/Reddit4
    Side effects, quotes and full profile
  2. Tesamorelin + Ipamorelin

    Synergistic GH release, theoretical, Belly fat, via tesamorelin, Deeper sleep, anecdotal

    03 Deeper sleep, anecdotal

    • Users report faster/deeper sleep and vivid dreams within days-2 weeks, better recovery, and midsection fat loss after ~6-12 weeksanecdotal Reddit/forum161718
    Side effects, quotes and full profile

Questions about sleep

Which peptides are discussed for sleep?

DSIP, CJC-1295 without DAC, CJC-1295 + Ipamorelin, Tirzepatide, CJC-1295 with DAC, Epithalon, Sermorelin, Ipamorelin, Tesamorelin + Ipamorelin.

Which have the strongest evidence for sleep?

Labelled approved or trial-backed: Tirzepatide. Approval covers specific uses only.

Is any of this a recommendation?

No. humanpeptides.fyi makes no claims of its own. Each entry reports what cited sources say, with links. Talk to a licensed clinician.

Before you go in

humanpeptides.fyi is an educational index for adults. It summarizes and links to what others have published and reported about peptides and related compounds studied or used in humans. It is not medical advice and gives no dosing guidance. Many listed compounds are not approved for human use, and listing one is not a recommendation. Anecdotes are unverified. Images are AI-generated. By continuing, you agree to the Disclaimer and Terms of Use and the Privacy Notice.

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